STRUCTURE-ACTIVITY RELATIONSHIPS

Structure-activity relationships (SAR) analysis forms the bedrock in drug discovery. By systematically modifying the chemical structure of a lead compound and measuring the resulting biological activity, researchers determine the key structural features responsible for efficacy. This knowledge informs further development of novel therapeutic agents

Pharmacological profiling represents a crucial/essential/fundamental step in the development/synthesis/design of novel drug candidates. This process involves/encompasses/includes a comprehensive/thorough/systematic assessment of a drug's pharmacological/therapeutic/biochemical properties, aiming to elucidate/determine/identify its mechanism of acti